IL 1 B ( interleukin 1 , beta )
نویسندگان
چکیده
Other names: Catabolin; IL-1; IL-1B; IL1-BETA; IL1F2; pro-interleukin-1-beta HGNC (Hugo): IL1B Location: 2q13 Note: IL-1beta is a pro-inflamatory cytokine and is expressed by many cells including macrophage, NK cells, monocytes, and neutrophils. It belongs to the IL-1 family cluster that includes the IL-1a, and IL1-RN genes. The caspase 1 (CASP1/ICE) gene proteolitically activates IL-1β. This gene is involved in the proliferation, differentiation and apoptosis of cells. Inflammatory hypersensitivity has been found to be the result of IL-1β activation of cyclooxygenase-2 (PTGS2/COX2). IL-1beta has also been associated with septic shock, and wound healing.
منابع مشابه
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